Manuel I of Portugal born female

Okay, but Manuela and Charles are more age comparatible. Let's say that they marry in 1485 when Manuela is 16. Possible babies around 1488, perhaps?
 
Okay, but Manuela and Charles are more age comparatible. Let's say that they marry in 1485 when Manuela is 16. Possible babies around 1488, perhaps?

All well and good, but would Manuela not suffer the same fate as Lizzie of York when/if Marie of Burgundy's daughter is available.
However, Fernando and Isabel only married in October 1469, while Manuela is a May baby, so thin end of the wedge that that marriage might not occur, I guess.
 
Okay, let's kick the wedding up further. 1480. And have a pregnancy in 1486. But the possibility of Manuela being put aside is strong, but it might piss of Joao and I'm not sure that France want's to make a enemy out of Portugal.
 
Okay, let's kick the wedding up further. 1480. And have a pregnancy in 1486. But the possibility of Manuela being put aside is strong, but it might piss of Joao and I'm not sure that France want's to make a enemy out of Portugal.

What's Portugal gonna do about it? Castile-Aragon is between them and the Pyrenees (Castile-Aragon who don't like João either). England was across the Channel and presumably had Edward IV not kicked the Easter after the Christmas his daughter was dumped, they would've made a pretty big fuss about it (pairing up with Emperor Maximilian and the dowager duchess of Burgundy).
 
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