Say, for whatever reason, Mangazeya trade route doesn't get probihited by Russian government. English will have the access to Siberian furs remain open to them. As it has been pointed in my previous thread on the similar subject, it will be able to result in English/British rule in the Siberias.
Besides that though, what will be the other long term effects and potentials ? With Siberian furs in English hands, will Hudson's Bay Company still be formed ? If it won't, than who's going to exploit that land's furs. Also, how will this influence the course of history in Eastern Europe and Baltic regions ?