If the Holy Orders had fallen more literally under the domain of the Papacy, it could easily have happened. The Templars were a proto-bank n many respects, including aspects of international cheques...you could deposit your money with, say, the Templars in Paris or London, receive a receipt, and withdraw it in somewhere like Jerusalem. The Papal Beauracracy could have taken that and run with it. It would also mean no Medicci empire, as their transformative role as papal banker wouldn't have existed.
It could have affected Europe tremendously, in varying ways. If the Pope wields his religious authority to further financial advantage as he did with the political, you might see an earlier Reformation. Or, conversely, that acquired wealth might be powerful enough to stem resistance, fund internal reform or make aspects like indulgences unnecessary, meaning it might lower the odds of any real Reformation. There's also the chance it fuels a massive expansion of the Papal States, fulfilling their interpretations of the Donations of Constantine/Carolignians, which would obviously be a huge game-changer.
So much depends on when this happens. Did you have anything specific in mind?