Barbara Zapolya does not die in 1515:
Sigismund I (1467-1548) Grand Duke of Lithuania, King of Poland, m. Barbara Zapolya (d. 1547)
1) Hedwig (1513-1573) m. John (1513-1571) Margrave of Brandenburg-Küstrin, has issue
2) Anna (1515-1520)
3) Sigismund II (1517-1568) Grand Duke of Lithuania, King of Poland 1548, m. Elizabeth of Austria (1526-1571)
1) Sigismund (1546-1549)
2) Hedwig (1549-1602) m. John III (1537-1592) King of Sweden
3) Barbara (1551-1582) m. John Frederick (1542-1600) Duke of Pomerania
4) Elizabeth (1557-1559)
4) Elizabeth (1520-
5) Sophia (1522-1590) m. Albert (1522-1562) Margrave of Brandenburg-Kulmbach [1]
1) Susanna (1546)
2) Albert Casimir (1548-1553)
3) Sigismund (1550-1621) Margrave of Brandenburg-Kulmbach, Duke of Prussia 1618, m. Dorothea of Brunswick (1557-1599) see below
4) Barbara (1554)
6) Anna (1525-1582) m. Charles Victor (1525-1577) Duke of Brunswick-Wolfenbüttel
1) Henry (1548-1552)
2) Charles Sigismund (1550-1604) Duke of Brunswick-Wolfenbüttel, m. Sibylle of Cleves (1557-1627)*
3) Barbara (1552-1558)
4) John Henry (1555)
5) Dorothea (1557-1599) m. Sigismund of Brandenburg-Kulmbach
6) Sophia (1561-1623) m. Ferdinand (1529-1595) Archduke of Tyrol
7) Vladislaus IV (1527-1596) Grand Duke of Lithuania, King of Poland 1568, m. Elizabeth of Austria (1554-1592)
1) Sigismund III (1572-1623) Grand Duke of Lithuania, King of Poland 1596, m. Anna of Brunswick (1578-1634) [2]
4) Hedwig (1575-1610) m. Maximilian I (1673-1651) Duke of Bavaria
5) Vladislaus (1580-1600)
6) Barbara (1583)
[1] Albert is raised as Catholic ITTL as his father does not die in 1527. His son inherits Duchy of Prussia after death of Albert Frederick in 1618, being his closest male relative.
[2] Daughter of *