With a POD after 1500, how much can we diminish the popularity of tobacco-smoking globally?
Are you looking for less popular today or never really became popular?
The pope forbids it, as it was an herb used in indigenous religious practices. Thus, Nicot doesn't spread its popularity with the European aristocracy and the product only remains popular amongst indigenous people and probably the lower classes throughout the continent.
The pope tried to ban forks and crossbows.
Guess how successful that was.
Just start a rumor that says smoking tobacco is part of some savage Indian ritual and makes you vomit. That's why some of the other tobacco alternatives aren't popular.