Latest Possible Missile Development

What is the latest possible time that guided missile development (air-to-air, etc.) could be pushed back? The Nazis first used guided missiles operationally during WWII, but is there a way we could retard Germany's growth in missiles, for example not have Hitler be so obsessed with the V weapons? Would the lack of the Nazi's example slow down the West or the Soviets? What about problems with the infrared or radar algorithms needed for targeting?
 
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