Admittedly, this is a stretch, but OTL Alexander of Poland was married to Elena Ivanovna of Moscow, and died childless, being succeeded by Sigismund I on his death in 1506. However, Elena was pregnant twice (1497 and 1499), but miscarried both times.
Now, say Elena had birthed a live child, who lived to succeed his father as king of Poland and grand duke of Lithuania - Alexander II (or John II, IDK). On the surface, it doesn't seem like much, but what happens if and when the Muscovite/Russian line of succession starts looking none to secure - for instance, Vasili III dies without a son and heir (and considering his brothers weren't allowed to marry until he had said son and heir, it's probably not inconceivable that they would do so here - Yuri Ivanovich had no children, and Andrei Ivanovich of Staritsa only had one before he died).
*I know, this needs to keep a pretty close-mesh butterfly net in place...
Now, say Elena had birthed a live child, who lived to succeed his father as king of Poland and grand duke of Lithuania - Alexander II (or John II, IDK). On the surface, it doesn't seem like much, but what happens if and when the Muscovite/Russian line of succession starts looking none to secure - for instance, Vasili III dies without a son and heir (and considering his brothers weren't allowed to marry until he had said son and heir, it's probably not inconceivable that they would do so here - Yuri Ivanovich had no children, and Andrei Ivanovich of Staritsa only had one before he died).
*I know, this needs to keep a pretty close-mesh butterfly net in place...