Karl II of Guelders

What if Karl II, Duke of Guelders had had a legitimate child to succeed him? He married Elisabeth of Brunswick in 1519, but he died twenty years later with no children by her, although he had several bastards.

How might the Burgundian Netherlands look with Gelderland taken out of it. And what effects might this have on German-Dutch politics of the day? And most importantly, would Karl V have allowed it?
 
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