First stage of that war (Venice vs the rest World) should not be affected, but if son of Ferdinand II of Aragon and Germaine de Foix lives to adulthood, would Ferdinand still join Holy League in 1511? According to Treaty of Blois between Ferdinand and Louis XII, Louis passed his rights to Naples to his niece-Germaine, and her descendants, if Ferdinand and Germaine had no kids, these rights would return to the French Crown. IOTL Ferdinand and Germaine had no surviving children, but if their son, John, Prince of Girona was still alive in 1511, how would Ferdinand behave? He would want Navarre, and possibly be concerned about French expansion in Italy, but at the same time he would be concerned about future of his young son on Aragonese throne, and alliance with France would seem natural in such circumstances-French could be helpfull in keeping Habsburgs out of Aragon and prevent totall Habsburg encirclement of France. So isn't it bad idea to piss of France in such situation?