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Maximilian I, Holy Roman Emperor, made two marriage alliances with Ferdinand of Aragon and Isabella of Castile. The most famous one is that between his son, Philip and Joanna (Juana), the daughter of Ferdinand and Isabella. However, there was also a marriage alliance between Maximilians daughter, Margaret and the son of Ferdinand and Isabella, John (Juan). The latter, however, died in 1497, at the age of 21 and the crowns of Castile and Aragon therefore fell to Juana and Philip. Because of this, their son, Charles V, inherited their parents domain, and that of his paternal grandfather (Maximilian survived his son, Philip).

So, the question: What could be some possible butterflies if Juan, the son of Ferdinand and Isabella had survived to old age and if Philip had died before he got any child (meaning that Juana was not pregnant at the time of his death)? This would mean that neither Charles V, nor his siblings, were ever born.
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