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Basically, Isabel Neville lives until the 1480s, maybe 1489. She gives her husband a few more children and manages to keep him more out of trouble, thus giving him a shot at the regency and allowing Edward V to live longer. For reference, here is the ITL family tree as of 1485:
George Plantagenet, 1st Duke of Clarence, 1st Earl of Salisbury and 1st Earl of Warwick (b.1449: d.1504) m. Isabel Neville (b.1451: d.1499) (a)
1a) Anne of Clarence (b.1470: d.1480)
2a) Margaret of Clarence (b.1473) b. Frederick of Saxony (b.1463)
3a) Edward of Clarence (b.1475) b. Anne St Leger (b.1476)
4a) Richard of Clarence (b.1476: d.1477)
5a) Ursula of Clarence (b.1479) b. Edward Stafford (b.1478)
6a) Cecily of Clarence (b.1480: d.1480)
7a) Edmund of Clarence (b.1482: d.1484)
8a) Isabel of Clarence (b.1485) b. Prince Christian of Denmark (b.1481)