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The American March westward is storied as it is tragic. The Indians were swept off their lands and into either extinction/assimilation/or reservations.
Many groups fought the encroaching American settlement till the beginning of the 20th century and even a little after.
How can we have the Indians put up the best possible resistance for as long as possible.
Delaying the trek across the Appalachians and march to California and closing of the west until say 2100
POD: is 1500
Have the Amerindians in North America hold on to the beginning of the 22nd century.