Indian Removal Act prevented

I doubt that being possible. Even without Jackson there is enough of anti-natives who would create such act.
 
But some individuals of the Five Civilised Tribes were extremely wealthy based on their use of plantation slavery, certainly they could be a powerful opponent against being removed.
 
But some individuals of the Five Civilised Tribes were extremely wealthy based on their use of plantation slavery, certainly they could be a powerful opponent against being removed.

At best, they would end up with reservations in the Deep South, rather than being forced to move en masse to Oklahoma. That land was prime cotton country, and the settlers would overwhelm them demographically even if they did stay more or less where they were.
 
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