Would there actually be much trade? If it's gold they want, then sailing to West Africa is certainly easier. Coastal Africans were generally not wealthy or particularly advanced in this era either (at least to my knowledge), so the Romans could still get great deals on gold (although this would mean a bit of a triangle trade where coastal Africans sell slaves to inland states for gold which they sell to Romans for goods). This was already a known trade since Carthage had been involved for centuries.
A huge problem is that to my knowledge, a lot of trading networks in the New World were fairly new in the days the Roman Empire was at its height, which means gold, silver, etc. will be in fairly short supply, if present at all, at the fringes compared to 1492. Maize was still rare north of Mexico, and unheard of beyond the Gulf Coast.
Based on Caesar's reaction to the druids and a general Roman distaste toward human sacrifice, that element found across indigenous American cultures will not be viewed positively, even if to my knowledge it wasn't quite at the scale it was in the later part of the Classic or Postclassic.
IMO the more interesting Roman scenario would be a 4th century one given the Americas are slightly more developed at that point and Rome now has a lot more internal tension and issues like Christianity vs paganism vs Christian heretics to contend with.
And considering how comparatively little we know of Pre-Columbian America, judging the impact there is extra hard.
Archaeology and early writings give us a good clue of the general trends of how regional economies functioned and how they reacted OTL to new items introduced through trade.