Could there be a conflict in which a bunch of states secede and attempt to form their own nation, and the National government fights to maintain the eternal union? And would these states be located in the general South? No, I dont think so. Of course States Rights was a lie and the Civil War was only about slavery, so the nature of that conflict cannot come to be in an America which has abolished it. There could be a Civil War, for example, maybe in the 1850s or so there is an extremely close fought election between a Whig (if the Party survives) and Democratic candidate in which the outcome is not accepted by the loser (maybe Congress refuses to certify the Electoral Votes of the winning candidate and selects the other one) and thus 2 factions fight for who is the "legitimate" givernment of the Unites States