Oh god, without the combined power of the other 49 states to keep Florida in check, the whole state is going to collapse into a lawless wasteland full of gator-riding gangs of retirees, Disneyworld costumed characters, and swamp men.
Carpet bomb the entire area with nukes. And then do it again, and again and again until the entire state has been reduced to bedrock.
It's the only way to be sure.