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The POD can be anywhere from 1700 to the beginning of the Revolutionary War.
Without the influence of slave-holding planters in the Deep South, would this US be significantly more socially progressive and racially tolerant that OTL?
How differently would this US develop demographically?
Does this US have the capacity to be a great power on the world stage?
Without cheaper labor available in the south and west, does the North see the same deindustrialization it did OTL with the development of the Rust Belt?
Do you see this US retaining a policy of isolationism?
Let's say that in TTL the Deep South is independent and the Louisiana territory is under the control of a friendly Britain which has no intentions of selling any of its land to the US.