How Two Fishermen Changed History

I've thought about your wish to create a disease-immune America, and I've got to say, I don't see any way it can realisitcally be done. We had Smallpox for 10 000 years, and we're not immune. The Plague swept through Europe over and over again over centuries, and even the hardest-hit areas have an immunity rate of 20 % today.

To be honest, I think your best bet here may be to make it an ASB. Just handwave in the immunities.

Toby the ASB passes near earth, and sees that the Old and New worlds are about to make contact. Being a moral ASB, he can't sit and watch the inevitable megadeath, so he makes the Americas immune to old world disease, and for fairness makes the old world immune to syphilis.
 
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Butterflies on Europe
On 1470, uncertain about her future after her father's death, Mary of Burgundy decided to marry Rene of Lorraine merging Burgundy and Lorraine completely after the death of Nicholas of Anjou, they have a son named after the father of Mary named Charles on June 4, 1471.

After the heartbreaking event that stopped the marriage of Isabella of Castile and Ferdinand of Aragon, the two had different lives and had also recovered from their own stopped engagement.

Isabella of Castile continued her life and had kids with Alfonso V of Portugal, their kids are; John(June 4, 1471), Anna(May 5, 1473), Isabella(December 4, 1475)

Life continued for Ferdinand of Aragon as he married a Byzantine Princess instead named Zoe Paleologina on 1471 and proclaimed himself the Basileus and annexed the old Duchy of Neopatria and the Despotate of Morea, they had children together; John(June 4, 1472) and Maria(August 4, 1473).

While John and Joan the respective monarchs of Castile and Portugal had a son on June 5, 1475 and he is named Manuel.

Ferdinand of Aragon was happy in this new marriage and he is said to have been the initiator of the 10th crusade against the Ottomans which started in 1480, he is said to have been helped by the other western states in crusading against the Ottomans and one of the participants of the crusade is Corombo, the Crusade also were able to regain Albania which was incorporated to the Kingdom of Sicily ruled by Ferdinand's cousin Ferrante.

Catherine of Navarre fell in love with Edward of Westminister and told him never to set sail back to England like what his mother told him, so they married on 1475 and ruled Navarre together, they have a son named Henry on June 4, 1480(Francis Phoebus is not born and a girl named Catherine replaces his place and becomes this ATL Catherine).

 
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The Destruction brought by the Sea Plagues

Due to the Destruction brought by the Sea Plagues the surviving Arawak and the Taino were violent and kill anyone who sails from the West and arrive to their island and due to this they were able to start to recover from the plagues, there are indeed few fishermen from the west who are stranded again but they meet bad treatment from the Arawaks and the Taino.

Due to the Plagues the Mexica fall and the Tarascans who were able to replace the Mexica after their fall due to the Tarascans inventing and figuring out how to mix their discovered how to mix Iron Ore with Copper and they found out that it makes effective weapons against their enemies like the Mexica and because of that the Tarascan army were able to subdue the Mexica.

The Tarascans proved to be more capable than the Mexica even if the Tarascans also suffered from the same diseases as the Mexica which meant that the Tarascans were exploiting a power vacuum in Mexica.

The Tarascans seemed to be so confident due to them defeating the Mexica but tough times are ahead for them.

On this time the Missisipians had also fell to the two plagues but were able to rebound a little but it maybe too late for them.
 
Asian Butterflies
Meanwhile, around 1450's, the Spread of Islam spreads more due to the Malays trying to settle Sulu and the peripheries of Maynilad and due to this, Alon, the ruler of Tondo converts to Islam before his death and he also influenced his son, Gambang to convert as well due to his region being settled by Muslim Malays and at this time the city of Maynilad still becomes contested by the other people in the Malay world.

Starting at the time of Gambang's reign due to Islam the population of the Island where Tondo is start to increase and homogenize causing Tondo to increase its grip in the Island and its surrounding environment, the title of Gambang is the Hari, Lakan or Rajah of the Tagalogs and Sultan title is added and because of that the Island where he is living is now called as Tagalia by Europeans but the Malays call it as Selurong but the people in the Island itself call it as Pulo na Katagalugan and at this time the people in the Center of Tagalia is starting to increase and dominate.

At this time on the late 15th Century a woman named Layla Mekanay from Sulu who is the only heiress of Sulu is keen enough never to marry a man who is desiring her inheritance, since her father is childless and he died early pushing Sulu into anarchy, Bolkiah tried to marry her but she refused and said she wants a man that cares about her own country and her heart and she is very strong willed and proud that she would never allow a man to force her to marry her so she had a very hard life and she often went into wars and she became the defacto ruler of Sulu but one thing was lacking in Sulu and that is a male Ruler.

Due to Layla Mekanai not marrying yet, another suitor from her cousins from the Kiram family attempted to marry her but she also refused to marry him and instead chose to follow her heart and that is she should have her own happiness in the end she was able to meet the person she would spend the rest of her life with.

Layla Mekanay went alot of trials due to her choice not to marry a powerful man who could annex her lands

Layla Mekanay decided to marry a man who is a minor ruler in an Island with the same name as Sulu or Sugbu and due to that the King of Sugbu also became the Sultan of Sulu as Mohammed I of Sulu.
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Layla Mekanay of Sulu as portrayed by Maryam Pahlavi, a mixed Persian and Tausug(Suluan) actress on the series Queen Layla.
 
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