Does literally every other Great Power wreck themselves in two major wars, as OTL? If so, then the US could probably establish itself briefly as a global hegemon; if OTL is a guide this hegemony might last 25 years if they're lucky. Short of that, the US would just be an even worse regional hegemon in the New World with some influence in the Pacific and/or Africa.
The US was really not anything like as powerful in the early-mid 20th century as it is commonly portrayed, it just had the very good fortune to be the last man standing. While it would have been the strongest state in the 20th century even without the world wars, the gap between it and powers like Britain and Germany would not have become overwhelmingly large until after 1950, by which point states such as Russia (which without world wars could easily outpace the US by the early 21st century) would begin to catch up. This is putting aside the rather important factor of 'who is allied to who'...