Canada gets captured during the Rev War, it rebells (with help from Britain and France) in the 1820's it wins and frees itself from the US and takes an significant chunk of it with them.
I don't think So.
If the Colonies had taken [&held] t Quebec in the ARW, Britian would have abandoned Canada & the Maritimes. France had already agreed to the Colonists taking Quebec.
By the 1820's Immigration and Migration Patterns mean the parts of Canada would consider themselves fully Americans.
However with out the War of 1812, Sectionalism could be a stranger force in American Politics.
Tensions in the South over Tariffs & Nullification, Tensions in the West over French Louisiana & the Mississippi. [No French Sale]
Tensions between NY,& New England [Includes OTL Maritimes] over the Erie Canal/St Lawrence. Tension with Quebec over Anglos dominating Quebec's Politics.
Tension with Britain over Trade and never resolved ARW issues. [No Jay Treaty 1795].
The Right Spark, And the US Implodes.