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Peter the Great. Started a timely modernization program of unprecedented vision and scale. The Czar himself went to Britain to learn the art of ship building under an assumed identity. No other monarch could claim to have personally made so much difference to his nation's character.

Genghis Khan. Enough said. DNA science as revealed millions of East Asians are related to him due to the large number of women he and his relatives acquired. No one man has had so much genetic impact on the modern world.

Muhammad. Great conquerors come and go. Their empires often falling apart soon after the founder's death. But he built an empire of faith which consolidated the physical empire, and it still commands a fanatical following today.

Thomas Edison. Way too many inventions to not raise eyebrows.
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