Let's assume that someone decides that he can't live under the rule of a heretic (and possibly insane) king and decides to take matters in his own hands.
Can this happen before Anne Boleyn is crowned and bears him Elizabeth, that is between 1532 and 1533, or do you see it more likely that a cabal of papists (for lack of a better word) forms after 1535 when Fischer and More are executed?
Is the latter faction still strong enough to take power? Will this trigger a civil war or is Mary's going to have a smooth succession? Who's going to be regent? Will Spain accept to deal with regicides?