Henry VIII and the Kell Mutation

I recently came across an article that asserted that Henry VIII's reproductive woes were caused by his having Kell positive blood (a rare blood mutation). This was supposedly inherited from his great-grandmother, Jacquetta of Luxembourg. If this were true, then it would stand to reason that Henry's other male relatives on his mother's side would have had the same problem. Did they? I recall that Henry Stafford, Duke of Buckingham, had numerous children by his wife, Catherine Woodville, who was Queen Elizabeth Woodville's sister. Does anyone know how fertile the other Woodville marriages were? I do remember that Anthony Woodville had no children..
 
Not likely:
Queen Elizabeth Woodville's first son by her first marriage -
Thomas Grey had 14 children his heir (who would be the same generation as Henry VIII) had at least 8
All the Queen's brother's did die without legitimate issue -
Anthony - married twice no issue
John married a woman to old to have issue and was executed
Lionel entered the church
Richard never married.

Of her sisters
Jacquetta Woodville - Had one daughter -who had issue
Anne Woodvile - had one son and two daughters by her first marriage. Her son the 2nd Earl of Essex left only one daughter who died childless
She had a son by her second marriage Richard 3rd Earl of Kent who died childless.
Mary Woodville - had one daughter - who had issue
Catherine Woodville - had two sons and two daughters - her sons
the 3rd Duke of Bucks had 3 daughters and one son. His brother Henry Earl of Wiltshire had no children.
Margaret Woodville had several children including her son William 18th Earl of Arundal who had one son of his own.
Joan or Eleanor - had no children.
 
Henry's huge problem with probably having no issue after Edward VI stems from his sporting injury in the 1530s that left his leg unable to heal. He gained a lot of weight and he probably became impotent. Aside from the short marriage with Anne of Cleves, he was next married to Katherine Howard and she never conceived, although there were several pregnancy rumors. He also had no issue with Katherine Parr. I don't think it has anything to do with the Kell Mutation. Simply he had gained so much weight and it had rendered him impotent.

Anne Boleyn also quite possibly had her own genetic issues. I forget the name of the disease, but essentially, the mothers first child is healthy and born to term. Any other pregnancies end in miscarriages because the body sees the foetus as foreign and "kills" it, so to speak.

As for Katherine of Aragon, I've heard that during many of her pregnancies she had a terrible diet (she continued to fast even when pregnant) and would also spend a lot of time at prayer on the cold stone: it certainly could've contributed to her many miscarriages as well as weak children who died young.

Simply put: Henry VIII was just really unlucky.
 
Absolutely
There certainly wasn't a fertility issue:
Katherine of Aragon had at least six pregnancies in a decade producing three live births (two sons and one daughter)
Anne Boleyn was pregnant at least three times (Elizabeth, a stillbirth and possibly a miscarriage)
 
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