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So, this thread here: https://www.alternatehistory.com/forum/threads/mary-i-of-scots-ii-of-england.413481/ got me thinking, what might the consequences be if in 1546, whilst Henry VIII is away in France, Elizabeth and Mary both die from perhaps the sweating sickness, and then in 1547, Edward dies from any number of ailments. Henry would most likely return from France at this point, and perhaps as with Isabella of Castile forty years before, the grief from losing so many kids, and his own poor health finally gets him. However, whilst he is on his death bed, without any of his own issue surviving. who does he decide succeeds him? His sister Mary's descendants in the person of Frances Grey Duchess of Suffolk, or his sister Margaret's descendants?
If he goes with Frances, does this lead to a breach within England itself, and potential civil war? What does this do for the religious situation in England as well?