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http://en.wikipedia.org/wiki/Heinkel_He_219 http://www.historyofwar.org/articles/weapons_he219.html
Possibly one of the most effective night fighters of the war, the 'Uhu' was opposed by Erhard Milch, Inspector General of the Luftwaffe, who cancelled it because of his investments in other, ultimately less effective aircraft. What if it had been mass produced instead of halted after ~250 units were produced?
Obviously it wouldn't be a war winner, but it could have a major effect on the airwar against the RAF, specifically because it could intercept the mosquito, which had been previously untouchable. Furthermore it had advance radar equipment that allowed it to operate independently of ground control once directed to a bomber stream.