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Say Margaret of Austria, daughter of Emperor Maximilian I, is more lucky with her second marriage-she has few kids with Philibert, who, of course, avoids his hunting accident (say both live to 1534). So not being widowed again Margaret does not return to the Netherlands, she is never proposed to Henry VII and is not made regent for her nephew after death of Philip (assuming his death in Spain is not butterflied away). H7 would still have CoA and Juana la Loca to distract his attention, so he's still likely to not marry again so I'll leave this topic unchanged.
And about the kids: say they have 5, three surviving:
*Margaret, born 1502
*Philip (1504-1508)
*Philibert, born 1505
*Mary, born 1508
*Louis (1510-1512)

Margaret could end as Queen of Poland as second wife of Sigismund I, IOTL Maximilian proposed him his another granddaughter, Eleanor, but he widthrew, due to fact, that she was promised to Manuel of Portugal, he couldn't refuse her hand to Manuel without causing troubles for his grandson in Spain, and Max had no other spare, marriagable granddaughters, ITTL Max would want Siggie to marry his Savoy granndaughter-such match would seem more likely to prevent Sigismund from seeking for anti-Habsburg alliance again than Bona Sforza. Bona could marry her Sforza cousin, Massimiliano, thus increasing chances of Sforzas to keep power in Milan.
Now return to Netherlands-lack of Maggie here would influence lives of many people, her nephew, nieces and even Boleyn family. Who is going to take regency over Burgundia Inheritance?
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