Bring out your dead - disease
One of the biggest problems for any army in history was disease.
It's sometimes hard to remember that the germ theory of disease was only really being developed in the mid-nineteenth century, something as elemental as washing hands between treating patients dates back less than two centuries, and that Sulfonamide and Penicillin drugs were first developed in the 30s and 40s.
With that in mind, it should be understood that the cause of most casualties in most wars was disease - not bullets, not artillery, but disease.
Let's take one example first.
On their retreat through Poland in the 1810s, the Russians practiced a scorched-earth campaign. (This is itself tricky, but they did a fair bit of damage.) The result was that the area was disrupted and people were displaced from their homes - so sanitation broke down.
This resulted in a typhus epidemic - just as the Grande Armee passed through.
Now, the Grande Armee consisted of young men in hundreds of thousands, who would be dirty and sweaty (hot summer, marching tens of miles a day, and at war) and living in the same clothes for days.
Typhus is spread by lice.
The Grande Armee was essentially torn to shreds by Typhus. Within a month, he had suffered 16% casualties - 80,000 men were unfit for duty or dead, due to the disease alone.
One two week period slashed his combat effectives count from 160,000 to 103,000 - mostly from Typhus - and the total casualties caused by the disease are hard to determine but may have been well over half the entire Grande Armee's losses. (This may explain why Napoleon was down to 100,000 men from 500,000 by the time he reached Moscow - not General Winter, but the summer, reduced his numbers by hundreds of thousands of men. Ironically, the winter may have saved those who survived.)
More generally, armies are almost always great places for disease to build up. Unwashed, tired men in close proximity (to each other and dead bodies), without enough food, often sleeping in cold and damp conditions with weakened immune systems, possibly with minor injuries, sharing food, wading through mud or dirty rivers, and (if the army does not have excellent sanitation and self-control) with shit everywhere. Almost the ideal way to catch disease. (snip)