The Persians themselves were in a bit of a rut and needed reform. Meanwhile Anatolia was a province far from the Persian Core. It says a lot that Darius was pretty willing to hand over Anatolia to Alexander.
Meanwhile Macedon was a country with a decent geographic/agricultural base (Areas we refer to as Thrace and Macedonia) and a state apparatus that was reformed along Persian lines. It was also a military power with a technological and organizational edge.
If Macedon doesn't collapse into Civil War, I don't see why anything less than the conquest of western Anatolia by Macedon is to be expected.
Something like the lands of Cassander and Lysemachus during the Diadochi period. Macedon would control Macedonia, Thrace, and Anatolia de jure and de facto whereas Southern Greece would likely remain Macedonian De Jure but not De Facto just as with Cassander .
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