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Here's another idea for a POD that I thought up of: Alexander the Great was almost killed at the Battle of the Granicus River but he was saved by one of his bodyguards right in the nick of time. Let's say the bodyguard doesn't come in time and the lucky Persian soldier kills Alexander. Discuss the consequences if:
A) The Macedonians still win in OTL.
B) The Persians defeat the encroaching Macedonian army.