I'd say it depends on what period of time you're talking about. The likelihood of either the Lakhmids or the Ghassanids conquering all of Arabia drops hard the closer you get to Muhammad's birth. The webs of tribal alliances have already formed into powerful confederations between the settled Arabs like the Quraysh clans (who provided infantry and capital) and the nomadic Bedouin groups like the Hawazin (who provided high-quality cavalry and experienced scouts) when Prophet Muhammad bursts on to the scene. The only reason, imo, that Muhammad/Abu Bakr were able to pull off unification was that Islam had already played merry hell with tribal loyalties and alliances. Even with Islam softening things up, the Muslims were almost obliterated repeatedly by Quraysh calling in their tribal allies; I don't think the Lakhmids or Ghassanids would stand much of a chance.