As we know from OTL, Otto von Bismarck was the master politician whose actions broke German dualism and helped create the German Empire under Prussian hegemony. Whilst I do not exactly subscribe to the Great Man Theory (since it misses underlying societal, technological, or environmental factors often), one cannot deny Bismarck's handiwork on modern Germany and Europe as a whole.
So what happens if we remove Bismarck from the picture? Say he isn't born to begin with, or a girl is born in his stead. With OvB out of the picture, how would the German Question be answered?