Yep..I am talking about England.You mean in England?
Mary and Francis' enemies in the court would be protestants so marriages with the Portuguese/Spanish might happen..
That certainly works better - as a pod
Mary Tudor's personality is also likely to be much better in a tl which sees her legitimacy maintained, her father remain Catholic and her married. Less likely to be religiously as dogmatic as she was in otl. The good things about Mary - her kindness and loyalty in particular - are likely to be stronger. She will remain a conventional Catholic and Francis I turned more to clamping down on Protestantism in France in around 1534.
Renee of France was already in Italy and didn't return to France until 1559. Margaret of Anjouleme's relationship with Anne Boleyn is conjecture rather than fact - Anne was in Claude's household for a time and certainly wrote of Margaret with affection whether it was returned is again debatable - Margaret was not a protestant though she did believe in reforming the church and did intervene with her brother the King for compassion for reformers with some small success (in that she was closer to Anne's views)
There is no reason to think Mary will not be happy at the French court - she was attractive in her youth and had a pleasant personality. Her pro-Spanish views will perhaps not be as strong as in otl given there is no estrangement with her father and the view that her only support is coming from the Spanish - though she will have a friend at court in the presence of Queen Eleanor (her maternal cousin).
However her husbands imprisonment in Spain might have affected his view of Spain and so might mistrust his wife's pro-Spanish feelings.
Catherine de Medici was looked down on by the French court because she wasn't out of the top drawer so to speak - her childlessness also didn't help matters - her relationship with Mary could be difficult - though if they both have difficulty getting pregnant that might bring them together - but every heir Mary produces will move her brother in law further down the succession.
Mary's health will certainly be better in this tl - however her husband probably had TB (from his imprisonment in Spain) so it might well be that she like her mother has difficulty carrying children to term though she might conceive quite easily (as did most of her mother's family).