In the medium term, if the French Empire remains there, things stay frozen. The Roman question remains a serious running sore for Italy. France is not going to exchange their protection of Rome for anything that Italy could possibly offer in exchange through ordinary diplomacy. A negotiated settlement is a possibility, but it hinges on changes in French domestic policy, and arguably on a more conciliatory stance by the Papacy itself (unlikely in the immediate; quite possible in the longer term). As long as the stability of the Napoleonic regime depends (or is perceived to depend) from Catholic support at home, AND the Papacy remains defiant, there is little that Florence can do, short of risking outright war with France and/or seeking alliances to that effect. Itself not easy, given the importance of Franco-Italian economic (and cultural) ties in this period.
Now, things may be interesting when Tunisia becomes an issue around 1879; but Italy is not going to trade Rome for Tunis, and French Catholics would see the opposite concession as betrayal (maybe, however, their political clout is diminshed enough that an agreement can be made on these terms: the French ditch the Pope, and Italy lets them do whatever they want in North Africa).
Sardinia is a complete nonstarter; I doubt that France was ever interested enough to make it viable anyway.
The longer the situation goes on, of course, the more anti-French Italy is likely to turn, probably aligning much more closely with, well, I suppose Prussia. You may see a context where "Italia irrendenta" means Rome, Nice, Corsica and maybe Savoy (and Tunis perhaps, depending on how that goes), much more than Trento, Trieste and Istria.