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Let's assume that the 1680 Pueblo Revolt succeeds and in 1692 to 1696 reconquest doesn't succeed. I have a pretty good idea the effects it would have on the Pueblos, a more warlike society and possible migration to more defensible areas and a larger percentage of their population assimilated into the Navajo among others followed by possible cultural extinction simular to what happened to the Mound Builders.
But what would it mean for New Spain and Mexico. Would we have the Monterrey Trail rather than a Santa Fe Trail? Would the French move further west? No Texas?