Empress Isabella's miracle

Isabella of Portugal b 1503, Holy Roman Empress and queen of Spain died in 1539 at the age of 36. If the empress were to survive until somewhere around 1555 or so what would be the consequences for the future?

I just really like her as a person and queen and it's a interesting subject to explore.
 
Isabella of Portugal b 1503, Holy Roman Empress and queen of Spain died in 1539 at the age of 36. If the empress were to survive until somewhere around 1555 or so what would be the consequences for the future?

I just really like her as a person and queen and it's a interesting subject to explore.

Perhaps a second son? Although I'm not sure why he'd survive when none since Felipe have made it past a year.
 
Isabella died of a premature abortion, so maybe if the baby is born at full term and a second infante for Spain she can survive? Or have infante Ferdinand live to adulthood. The empress might have had malaria at that time, so perhaps she can get better.
 
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