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Just an idea: Elisabeth Farnese, the second wife of Philip V of Spain, has a miscarriage during her first pregnancy that makes her unable to have more children. What could be the consequences of no Charles III and his siblings? And assuming that Philip's earlier sons have the same fate as IOTL (Louis I dies young and Ferdinand VI marries a Portuguese infanta that is barren as well) how could go the line of Spanish sucession?
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