Earliest possible, Pan-Europe conflict?

In OTL, the idea of a regional conflict esscalating into a massive free-for-all among powers across europe didn't really appear in the form we know it until the Thirty Years War. Is it possible for it to happen sooner?
 

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In OTL, the idea of a regional conflict esscalating into a massive free-for-all among powers across europe didn't really appear in the form we know it until the Thirty Years War. Is it possible for it to happen sooner?
Rome survives, expands, suffers a massive civil war.
 
Conflict between the Roman Empires (southern and western Europe) and the Huns (Central and eastern Europe)?
 
Possibly something involving a France vs. HRE struggle, though that only is the center and west of the continent for the most part.

This wouldn't be based on anything OTL, though.
 
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