October 2, 2006: Family Guy Video Game! was released for the PlayStation 2 and the Sega Galaxy by Take-Two Interactive under the Acclaim label.
October 4, 2006: Star Trek: Encounters was released for the PlayStation 2.
October 8, 2006: Scarface: The World is Yours was released for the PS2, Sega Galaxy, Nintendo GameCube and Windows, with a port for the PlayStation 3 and the GameCube X to be released as launch titles.
October 10, 2006: The Legend of Spyro: A New Beginning was released for the GameCube, PlayStation 2, Sega Galaxy, Game Boy Advance and the Sega Gizmondo.
October 17, 2006: Justice League Heroes was released for the PlayStation 2, GameCube, Sega Galaxy, Nintendo DS and the Sega Gizmondo.
October 17, 2006: Justice League Heroes: The Flash was released for the Game Boy Advance.
October 20, 2006: Pre-orders begin to appear on the new GameCube X and the PlayStation 3 consoles, set to be out this November. One of the titles up for pre-order was Rare's newest game Viva Pinata.
October 20. 2006: Dale Earnhardt's NASCAR Racetrack 2007 was released for the GameCube by Microsoft, with a port of the GameCube X serving as the system's launch title.
October 24, 2006: Tom Clancy's Splinter Cell: Double Agent was released for the PlayStation 2, GameCube and the Sega Galaxy, with a port for the GameCube X and the PlayStation 3 coming as the system's launch titles.
October 24, 2006: Matthew Goggin's Pro Golf 2007 was released for the Nintendo GameCube by Microsoft.