We'd get a Valois Poland (if Siggie still gets his VD from Signora de Cardona) earlier than OTL. Or a Valois Hungary (pursuant to Zapolya's 1528 offer to name one of François' sons as his heir). France would pretty much rumble on as OTL until François I dies. If Isabella was married to the dauphin, and they were childless, go to OTL. If Isabella were swapped in for Henri II after his marriage to Caterina de Medici was annulled, then we go more or less as OTL until Henri dies. Henri will likelier have healthier and longer lived kids though*, presumably who leave issue. So we might see a Valois UK if he has a second son old enough to marry Mary, QoS from the get go**.
*Also Diane de Poitiers might be given her congé earlier here (like reign of François I earlier) since Isabella is NOT Caterina
**assuming Mary, QoS still exists that is, but my opinion is that HAD a younger son of Henri II existed (aka who could be sent to Scotland) who was close enough in age, Mary would've been married to him instead of creating the logistical nightmare of a Franco-Scottish union. Of course, the Valois UK assumes that Edward VI, Mary I and Elizabeth I all still die childless as OTL. Liz would definitely be under pressure to marry if Mary had had a Catholic heir by 1558-60.