Once again, it was in New York that the answer emerged most emphatically. At the outset of the Poughkeepsie convention, anti-Federalists held a strong majority. The tide turned when word arrived that New Hampshire and Virginia had said yes to the Constitution, at which point anti-Federalists proposed a compromise: they would vote to ratify, but if the new federal government failed to embrace various reforms that they favored, "there should be reserved to the state of New York a right to withdraw herself from the union after a certain number of years."
At the risk of alienating swing voters and losing on the ultimate ratification vote, Federalists emphatically opposed the compromise. In doing so, they made clear to everyone -- in New York and in the 12 other states where people were following the New York contest with interest -- that the Constitution did not permit unilateral state secession. Alexander Hamilton read aloud a letter at the Poughkeepsie convention that he had received from James Madison stating that "the Constitution requires an adoption in toto, and for ever." Hamilton and John Jay then added their own words, which the New York press promptly reprinted: "a reservation of a right to withdraw" was "inconsistent with the Constitution, and was no ratification."