Dire Wolves, Saber tooths and, Mammoths instead of Native men.

How would colonization of the new world be different if instead of Native tribes in the Americas we have super large apex predators, and even larger herbivores?
 
How would colonization of the new world be different if instead of Native tribes in the Americas we have super large apex predators, and even larger herbivores?

1600 - Each tiger fang, one pound!

1650 - Each tiger fang, 5 pounds!

1700 - Each tiger fang, 100 pounds!

1715 - ...is there any tiger out there?
 
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