According to this article, the Spanish established a fort for a brief time during the 16th century near Asheville, North Carolina. The authors of the article speculate a couple of PODs that could have arisen out of this...
1) What if the fort (and others like it established by Spain in the interior of the Southeast) had been permanently occupied, or at least occupied for a long period of time? The authors speculate that the Spanish may have attempted to hold the east coast of North America in such a case. What might have been the results of this? Could English settlement of North America have been prevented, or delayed significantly?
2) The authors speculate that the forts transmitted smallpox and other diseases to the local natives, which meant when the English established their colonies in the southeast, the tribes of the interior were either gone or so weakened that they could not effectively resist. So what if the forts had not been established, and the interior tribes had remained unaffected by the diseases before the English came? Could they have prevented the English from establishing permanent settlements (as the locals apparently did with the Roanoke colony in the 1580s)?
1) What if the fort (and others like it established by Spain in the interior of the Southeast) had been permanently occupied, or at least occupied for a long period of time? The authors speculate that the Spanish may have attempted to hold the east coast of North America in such a case. What might have been the results of this? Could English settlement of North America have been prevented, or delayed significantly?
2) The authors speculate that the forts transmitted smallpox and other diseases to the local natives, which meant when the English established their colonies in the southeast, the tribes of the interior were either gone or so weakened that they could not effectively resist. So what if the forts had not been established, and the interior tribes had remained unaffected by the diseases before the English came? Could they have prevented the English from establishing permanent settlements (as the locals apparently did with the Roanoke colony in the 1580s)?