Perhaps a China that was quickly unified by the Jurchen, instead of being divided between the Qing and Southern Ming until the 1860s, could have held up against the Europeans. Obviously the Lotus Wars and the Ming Restoration (and thus the Hui Dynasty) would have been butterflied, but some other alt-conflict between Qing China and European economic interests would have certainly occured, and may have gone more in China's favour.
If Zuo Liangyu hadn't crushed the usurper Ma Shiying's army, then the Ming may have fallen into civil war and Shi Kefa wouldn't have been able to annihilate Dodo when he tried to attack Yangzhou. No Zuo Liangyu to restore order in court, and no Shi Kefa to hold the Yangtze and consolidate the Southern Ming realm under the Hongguang Emperor, and the Qing may well have rolled over the rest of China by the end of the century.
One wonders if the Chinese would still have rebelled against the Jurchen at a later date and established another Han Chinese Dynasty. Unlike the Hui Dynasty, this one wouldn't have been a European puppet, and may have been able revitalize the country's culture and military in an earlier version of OTL's Xiong Dynasty.
Also, without the distraction of the Southern Ming, the Qing may have been able to end the tragedy of the Xi Dynasty before it and its succesor states completely depopulated Sichuan.