DBWI: What if Americans Aren't Immune To European Diseases?

This one might sound a little weird but just hear me out.
What if the spanish discovery of America played out the same way the same way the french discovery of Australia did, with the natives dying on massive scales from european diseases the had no immunity to?
What would happen to the Americas?
 
This one might sound a little weird but just hear me out.
What if the spanish discovery of America played out the same way the same way the french discovery of Australia did, with the natives dying on massive scales from european diseases the had no immunity to?
What would happen to the Americas?

Well, for one, the glorious Socialist Kingdom of the Great Tawantinsuyu might not exist. Which sort of sucks for the guano trade later on.
 
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