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How could we get a scenario in which North America (South America too, but I'm focusing primarily on the French and British influenced places) is mostly devoid of Red Indians, or at least to the point where they constitute a miniscule minority?

For extra points, make it so that not only are there no Red Indians left, but whatever nations/peoples that replace them are relatively/mostly uninfluenced by the originial preoccupants of the continent.
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