DBWI: The Isabella of York marries Henry Tudor not Manuel I of Portugal

If Isabella of York(Elizabeth) marries Henry Tudor not Manuel I of Portugal, would Henry Tudor defeat Richard III and be crowned king?
 
The York alliance opened good markets for the Portuguese Guinean pepper.
There are articles saying there's a good chance the Portuguese might have fully opened the shipping lane to India, instead of the Spanish in the 1550's

I do wonder how Venice would have fared against the Ottomans if they had lost that spice trade earlier
 
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