DBWI: The Europeans Conquer the Americas

Literally the title, what if the europeans conquered the Americas?

As all we know, they tried, but after the defeats against the Inca and Aztec empires, the europeans lost their grip in the "Let's conquer them all!". The french gave up after the iroquoian conquest of Quebéc and the english after Achwon Ahoalgussit led the Lenape to drive out the settlers and the colony, the portuguese get the best local to settle but they lost all too after the rise of the Guarani Empire. And the last european attempt in the Carolinas drived out by the Tuscarora-led coalition.

In general, what if the europeans had more luck and established themselves in the american continent, rather than just stay with the caribbean and some trading posts under native jurisdiction?
 
Maybe Colonialism would still be a thing? I mean if they had been successful in America, maybe the various european powers could have focused their attention to Africa too.
I also wonder how this would have impacted on Venice and the Ottomans, especially if Spain had ended up owning the vast silver mines in South America
 
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