It hasn't been that long since the 33-year life of the Space Transportation System (STS) came to an end, so I believe that this is a good time to ask this question.
Looking into its history, there appears to have been a very serious debate over where to place the RS-25 engines, with some advocating placing them on the Orbiter itself to permit their reuse after each mission, while others (who won out IOTL) sought to place them on what became the Core Stage to lighten the Orbiter and increase the payload capability.
So the obvious question is: What would be the case, had the engines been mounted on the Orbiter?
Looking into its history, there appears to have been a very serious debate over where to place the RS-25 engines, with some advocating placing them on the Orbiter itself to permit their reuse after each mission, while others (who won out IOTL) sought to place them on what became the Core Stage to lighten the Orbiter and increase the payload capability.
So the obvious question is: What would be the case, had the engines been mounted on the Orbiter?