The US is massively interventionist on the American continents. The Mexican - American War, the Spanish - American War, the Fruit and Oil proxy wars, the Guyana 'Pliebescites'...
From that business with wrenching Canada out of the Commonwealth in 1936 (although the Brits REALLY didn't help their case there) and then 'buying' Newfoundland / Labrador in the Land Swap. To the current funny business with the Chavistas down in Venezuela. The only big difference between the US and Europe is that while European interventionism is global the US is 'local' with the two exceptions of the Philippines and Greenland.
No, the thing is getting the US to give a care about anything other than its own two continents... An all out war with Britain over something could do it, we've never been bestest buddies after all but even then I can't think of a provocation strong enough to override all sense as the continual hate between France and Germany has accomplished several times. We were interested in China for awhile also but the grand and glorious disaster the Euros, Japan, Chiang and the Yun family have made of the place I'm glad we cut out of there when we could...
I dunno, maybe something wrt middle east oil in more modern times? If coal gasification and natural gas fracking never take off to supplement Nixon's nuclear 'push' or the massive oil discoveries in Canada, Alaska and offshore I could see issues arising similar to whats happening to the Eurasian oil market atm with the massive unrest and the Pan Arab Spring.