Well certainly the other GPs hold onto their bits of Guyana/Suriname.
We also likely wouldn't see South American colonization of Africa at all, except -maybe- by a stronger Brazil.
An independent Venezuela stands a chance of becoming a second-tier oil producer in its own right, but its rivalry with a reduced Colombia likely leads it down a nasty path.
In the absence of a northern hegemon, the southern Andean nations could unite and become a major Pacific player instead of constantly bickering.
Perhaps Panama becomes the target of a Filibuster invasion? We could see US 'client' states all over Central America without Colombia there to cock-block the restless Dixies.